The track category is the heading under which your abstract will be reviewed and later published in the conference printed matters if accepted. During the submission process, you will be asked to select one track category for your abstract.
Cancer can occur anywhere in the body. The continuous growth of tumor cells can affect organ which can be lung, prostate, colon, rectum, stomach, liver, cervix, breast. Cancer are often described by the body part that they originated from. However, some body parts contain multiple types of tissue, so to be precise, cancer can be additionally classified by the type of cell that the tumor cells originated from. The type of cancer a person has needed to be known properly as diverse types of cancer can behave very differently and respond to different treatments. In that colorectal cancer is one of the organ specific cancer which begins with polyps which can be seen on the inner lining of colon or rectum and are further categorised based on polyps.
- Track 1-1Adenomatous Polyps
- Track 1-2Hyperplastic Polyps
- Track 1-3 Dysplasia
- Track 1-4 Bowel Cancer
- Track 1-5 Rectal cancer
- Track 1-6 Colon cancer
- Track 1-7 Adenocarcinomas
- Track 1-8 Gastrointestinal stromal tumors (GISTs)
Colorectal cancer are associated with hints or syndromes knowing them early can reduce the risk and can be prevented. One of the early clue of colorectal cancer is bleeding. The colorectal cancer depends on the position of the tumor in the bowel, and whether it has spread anywhere in the body. A routine screening must be carried to detect the presence of the colorectal cancer tumor and especially for aged people above 50 it is considered bit sensitive as they are more prone to get this disease because of the weak bowel system.
- Track 2-1 Change in bowel habits
- Track 2-2 Blood in the stool
- Track 2-3 Anemia
- Track 2-4 Abdominal pain
- Track 2-5 Weight loss
- Track 2-6 Vomiting
- Track 2-7 Diarrhea
- Track 2-8 Constipation
The colorectal cancer varies in different world regions. The highest colorectal cancer is noted in industrialized countries, and developed countries where Colorectal cancer is diagnosed high. The number of colorectal cancer cases increases in countries that undergo rapid economic transformations and adopt a Western lifestyle. This observation strongly suggests that one of the key mechanisms of carcinogenesis of colorectal cancer is associated with environmental factors. Current data suggest that lifestyle modification by addition of proper diet which is rich in vegetable, vitamins, fibers and reduction in red meat and fat, regular physical activity and exercise and maintaining an appropriate body weight may lead to reduce colorectal cancer risk.
- Track 3-1 Diet
- Track 3-2 Alcohol consumption
- Track 3-3 Smoking
- Track 3-4 Age
- Track 3-5 Obesity
- Track 3-6 Diabetes
- Track 3-7 Bowel diseases
All colorectal cancers induced by a heritable mutation – a genetic change that can be passed on from parent to child. The major subtypes of hereditary colon cancer and some rare conditions include an inherited risk for colorectal cancer. In some families if there is a strong hint or symptoms present genetically from ancestors, may pass that mutated gene from parent to offspring. The disease susceptibility of these families occurs randomly or by hereditary mutations which might not been observed that easily because mutation occurs in gene like APC, KRAS, TP53, SMAD4 which leads to grow cell uncontrollably resulting in Colorectal Cancer.Genetic counselors and physicians can help understand colorectal cancer risk and type based on it.
- Track 4-1 History & family background
- Track 4-2 Familial adenomatous polyposis (FAP)
- Track 4-3 Hereditary nonpolyposis colorectal cancer (HNPCC)
- Track 4-4 Attenuated familial adenomatous polyposis (AFAP)
- Track 4-5 Irritable Bowel Disease (IBD)
- Track 4-6 Inherited Syndrome
- Track 4-7 Lynch Syndrome
- Track 4-8 Mutation Associated Polyposis
- Track 4-9Peutz Jeghers Syndrome
- Track 4-10MUTYH Associated Polyposis
All cancer treatment is based on stages as each stage has their own variation. In Colorectal Cancer, this variation or treatment is determined by stages only which is divided to ‘TNM’-TUMOR, NODE, METASTASIS combination of this three will determine the stage of Colorectal Cancer which initially begins at stage 0 to stage 5. Tumor varies from T0-T4B, similarly for the node also NX to N2B and metastasis is MX-M1B.
- Track 5-1Stage 0
- Track 5-2Stage I
- Track 5-3Stage II A
- Track 5-4Stage II B
- Track 5-5Stage II C
- Track 5-6Stage III A
- Track 5-7Stage III B
- Track 5-8Stage III C
- Track 5-9Stage IV A
- Track 5-10Stage IV B
Colorectal Cancer is the fourth highest effected cancer which approximately takes around 85,700 life every year. The cancer which invades the bowel system or intestinal part including the rectum, colon etc. Mostly effects the developed countries because of the modern lifestyle with change in living environment, food and the aged people who have higher chances of being the victim of colorectal cancer. Screenings are carried out to determine the colorectal tumor cells presence or absence. Like other cancer disease Colorectal Cancer symptoms are not easily observed and quite difficult in aged people too continuous screening procedure help in reducing the risk.
- Track 6-1 High-sensitivity fecal occult blood tests (FOBT)
- Track 6-2 Colonoscopy
- Track 6-3 X-ray
- Track 6-4 CT-Scan
- Track 6-5 Stool DNA test (FIT-DNA)
- Track 6-6 Sigmoidoscopy
- Track 6-7 Double contrast barium enema
In Colorectal Cancer surgery is where the tumor is removed makes it the most common diagnostic method for all stages of colon cancer. The doctor may remove the tumor without cutting through the abdominal wall. Doctor may put a tube with a cutting tool through the rectum into the colon and cut the tumor or remove it from the effected region. If the tumor is larger, the doctor will perform a partial surgery where removing the tumor and a small amount of healthy tissue around it. The doctor may sew the healthy parts of the colon together. The doctor takes to examine the lymph node near the colon under a microscope to see whether they contain cancer. There are types of surgery for colorectal cancer.
- Track 7-1 Laparoscopic surgery
- Track 7-2 Colostomy for rectal cancer
- Track 7-3 Radiofrequency ablation (RFA) or cryoablation
- Track 7-4 local excision
- Track 7-5 Anastomosis
- Track 7-6Ablation and Embolization
Radiation therapy is a cancer treatment that uses high energy X-rays or other types of radiation to kill cancer cells and stops them from further growing. There are types of radiation therapy for treating colorectal tumor in Colorectal Cancer which uses a machine outside the body to send radiation towards the cancer or uses a radioactive substance sealed in needles, wires, or catheters that are placed directly into or near the tumor.
- Track 8-1 External-beam radiation therapy
- Track 8-2 Stereotactic radiation therapy
- Track 8-3 Intraoperative radiation therapy
- Track 8-4 Brachytherapy
Chemotherapy is a treatment that uses various drugs and medication to pause the growth of tumor cells, by destructing or by stopping the division of tumor cell. The chemotherapy is taken by mouth or injected into vein or muscle, the drugs reach the bloodstream and cancer cells throughout the body. Chemotherapy can also be done through applying the drugs directly on effected region or via cerebral fluid. Only a small amount of the drug reaches other parts of the body. The way chemotherapy is given, depends on the type and stage of the colorectal cancer being treated. There are different chemotherapy drugs for treatment of colorectal cancer.
- Track 9-1 Capecitabine (Xeloda)
- Track 9-2 Irinotecan (Camptosar)
- Track 9-3 Trifluridine/tipiracil (TAS-102, Lonsurf)
- Track 9-4 Irinotecan
- Track 9-5 5-FU with leucovorin and oxaliplatin (FOLFOX)
- Track 9-6Systemic Chemotherapy
- Track 9-7Regional Chemotherapy
- Track 9-8Adjuvant Chemotherapy
- Track 9-9NeoAdjuvant Chemotherapy
The treatment that uses drugs or other substances to identify and particularly target and attack tumor cells without harming normal cells is target therapy. For colon cancer, different type of target therapies is used like monoclonal antibodies, toxins and drugs approved by medical association for treatment of colorectal cancer which can identify tumor cells and block them from further growing or by further dividing . They are used to treat colorectal tumors that has spread to other regions of the body. The drug blocks the action of certain proteins, including vascular endothelial growth factor or certain cell signal pathways.
- Track 10-1 Anti-angiogenesis therapy
- Track 10-2 Bevacizumab
- Track 10-3 Cetuximab
- Track 10-4 Panitumumab
- Track 10-5 Regorafenib
Immunotherapy treatments can act as a catalyst or healer for ideal immunologic conditions that could increase the lives of colorectal cancer patients. The recent development of certain Immune-tool helps to classify tumors, identify the rate of survival in patients with colorectal cancers, providing precise diagnosis information that can improve the clinical decisions and treatment of patient. It is believed that if immunotherapy is used as cure not only in colorectal cancer but for other type of cancer diseases it will be a ray of hope for future medical research in diagnosing the disease early and to cure it.
- Track 11-1 Biological response modifiers
- Track 11-2 Colony stimulating factors
- Track 11-3 Tumor vaccines
- Track 11-4 Monoclonal antibodies
Exercise may be advised in the future as secondary therapy to colorectal cancer survivors. Exercise may reduce colorectal cancer. Results by doing the exercise proved to be beneficial to the patients. A measure of exercise, detected a reduction in the colorectal cancer mortality. Exercise benefits survival may be involved in immune and inflammation pathways. Oxidative balance may also reduce the colorectal cancer. Other solutions may involve metabolic hormone and steroid hormones. Palliative care is medical care which focuses on treatment from serious illness and improving quality of life. Its recommended for person who has advanced colon cancer or has significant symptoms, it may be beneficial to improve symptoms, anxiety and preventing admissions to the hospital.
Experiment & research proofs suggest that lactic acid bacteria may be protective against the development and progression of colorectal cancer through several mechanical functions like antioxidant, immune-modulation, programmed cell death and epigenetic modification of cancer cells. Large-scale genome sequencing studies have been done to identify mutations in colorectal cancer patients' genome and still the research is continued as it is believed that early recognition and treatment can reduce colorectal cancer.
- Track 13-1 Mouse model of colorectal cancer
- Track 13-2 The cancer Genome Atlas
- Track 13-3 The colorectal cancer atlas integrating genomic and proteomic data pertaining to colorectal cancer tissues and cell lines.
- Track 13-4Aspirin drug
- Track 13-5Oncotype Dx Screening
- Track 13-6Colon Cancer Assay
- Track 13-7Coloprint Dx Screening
- Track 13-8Hyperthermic Intraperitoneal Chemotherapy
- Track 13-9Immune Checkpoint Inhibitors
- Track 13-10Cancer Vaccines
Globally more than 1 million people get colorectal cancer every year. Colorectal cancer is more common in developed countries. Globally its 10-fold highest rates in Australia, Europe and USA. Colorectal cancer is the cause of cancer occurrence and death for men and women in the United States where an estimated 141,210 cases were diagnosed in 2011. Based on rates half of US men and women born today will be diagnosed with colorectal cancer, the median age at diagnosis for cancer of the colon and rectum in the US was 69 years of age. In United Kingdom & Australia colorectal cancer is fourth common disease as part of western and modern lifestyle and adapting new mannerism of eating habit which avoids nutritious content in food but involve more amount of fat content, lacking exercise and addicted to high consumption of alcohol and smoking leads to Colorectal Cancer in the developed countries compare to developing countries and making Colorectal Cancer a common health issue not only among old age people but among the young generation and even children also.